Biography
Professor TANG Wai Ho Jack is the Head of the Department of Health Sciences and Professor of the School of Nursing and Health Sciences at Hong Kong Metropolitan University. He also serves as Adjunct Professor and doctoral supervisor at Guangzhou Medical University, Deputy Director of the Institute of Pediatrics at Guangzhou Women and Children's Medical Center, and is the Chief Researcher of the Acquired Cardiovascular Disease Laboratory.
Professor TANG has been honoured in the National Natural Science Foundation of China's Outstanding Youth Project, Guangdong Provincial Special Support Program's "Top Young Talents in Science and Technology Innovation", Guangdong Provincial Outstanding Young Medical Talents, Guangzhou City's High-Level Health Key Talents, and High-level Talents from Hong Kong, Macao and Taiwan. He received PhD from the University of Hong Kong, and served as postdoctoral fellow and associate researcher at Yale University Cardiovascular Research Center in the United States. Currently serving as a reviewer for the journals "Frontier in Diabetes" and "Frontier in Cardiovascular Metabolism", a member of the American Heart Association, and a member of the North American Vascular Biology Organization.
Teaching Areas & Research Interests
- Vascular biology and therapeutic applications of platelets
- Pathogenesis of cardiovascular and metabolic diseases
Academic & Professional Experience
08/2023-Present Professor, School of Nursing & Health Sciences, Hong Kong Metropolitan University
08/2023-Present Adjunct Professor, Guangzhou Medical University
07/2015-07/2023 Professor, Guangzhou Medical University
07/2015-07/2023 Associate Director & Principal Investigator, Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center
07/2014-07/2015 Associate Research Scientist, Yale School of Medicine, Yale University
Selected Publications
Journal Articles
- Wen Y, Liu Y, Li Q, Tan J, Fu X, Liang Y, Tuo Y, Liu L, Zhou X, LiuFu D, Fan
X, Chen C, Chen Z, Wang Z, Fan S, Liu R, Pan L, Zhang Y, Tang WH. Spatiotemporal
ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm. Circ Res.
2024;134(11):1495-1511. doi: 10.1161/CIRCRESAHA.124.324323.
- Su M, Chen C, Li S, Li M, Zeng Z, Zhang Y, Xia L, Li X, Zheng D, Lin Q, Fan X, Wen Y, Liu Y, Chen F, Luo W, Bu Y, Qin J, Guo M, Qiu M, Sun L, Liu R, Wang P, Hwa J, Tang WH. Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis. Nat Cardiovasc Res. 2022; 1:732-747. doi: 10.1038/s44161-022-00108-7
- Guo M, Fan S, Chen Q, Jia C, Qiu M, Bu Y, Tang WH, Zhang Y. Platelet-derived
microRNA-223 attenuates TNF-α induced monocytes adhesion to arterial endothelium
by targeting ICAM-1 in Kawasaki disease. Front Immunol. 2022; 13:922868.
doi: 10.3389/fimmu.2022.922868.
- Zeng Z, Xia L, Fan S, Zheng J, Qin J, Fan X, Liu Y, Tao J, Liu Y, Li K, Ling Z, Bu Y, Martin KA, Hwa J, Liu R, Tang WH. Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation. Circulation. 2021; 143:354-371. doi: 10.1161/CIRCULATIONAHA.120.049715.
- Zhang Y, Wang Y, Zhang L, Xia L, Zheng M, Zeng Z, Liu Y, Yarovinsky T, Ostriker AC, Fan X, Weng K, Su M, Huang P, Martin KA, Hwa J, Tang WH. Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRbeta Vascular Smooth Muscle Cell Axis. Circ Res. 2020; 127:855-873. doi: 10.1161/CIRCRESAHA.120.316951.
- Zeng Z, Xia L, Fan X, Ostriker AC, Yarovinsky T, Su M, Zhang Y, Peng X, Xie Y, Pi L, Gu X, Chung SK, Martin KA, Liu R, Hwa J, Tang WH. Platelet-derived miR-223 promotes a phenotypic switch in arterial injury repair. J Clin Invest. 2019; 129:1372-1386. doi: 10.1172/JCI124508.
- Huang B, Chen Z, Geng L, Wang J, Liang H, Cao Y, Chen H, Huang W, Su M, Wang H, Xu Y, Liu Y, Lu B, Xian H, Li H, Li H, Ren L, Xie J, Ye L, Wang H, Zhao J, Chen P, Zhang L, Zhao S, Zhang T, Xu B, Che D, Si W, Gu X, Zeng L, Wang Y, Li D, Zhan Y, Delfouneso D, Lew AM, Cui J, Tang WH, Zhang Y, Gong S, Bai F, Yang M, Zhang Y. Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways. Cell. 2019; 179(5):1160-1176.e24. doi: 10.1016/j.cell.2019.10.027.
- Lee SH, Du J, Stitham J, Atteya G, Lee S, Xiang Y, Wang D, Jin Y, Leslie KL, Spollett G, Srivastava A, Mannam P, Ostriker A, Martin KA, Tang WH, Hwa J. Inducing mitophagy in diabetic platelets protects against severe oxidative stress. EMBO Mol Med. 2016; 8(7):779-95. doi: 10. 15252/emmm.201506046.
- Tang WH, Stitham J, Jin Y, Liu R, Lee SH, Du J, Atteya G, Gleim S, Spollett G, Martin K, Hwa J. Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets. Circulation. 2014; 129(15):1598- 609. doi: 10. 1161/CIRCULATIONAHA. 113.005224.
- Liu R, Jin Y, Tang WH, Qin L, Zhang X, Tellides G, Hwa J, Yu J, Martin KA. Ten- eleven translocation-2 (TET2) is a master regulator of smooth muscle cell plasticity. Circulation. 2013; 128(18):2047-57. doi: 10. 1161/CIRCULATIONAHA. 113.002887.
Selected Professional & Community Services
- Reviewer of Frontier in Diabetes
- Reviewer of Frontier in Cardiovascular Metabolism
Modified Date: 05 Nov, 2024
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