Staff Profile

Biography

Dr. Lai received his BSc and PhD from Hong Kong Baptist University. He completed postdoctoral training at the Institute of Molecular and Cell Biology in Singapore. Prior to joining Hong Kong Metropolitan University, he served as a Research Assistant Professor at the University of Hong Kong and as a Professor at Guilin Medical University. Dr. Lai has secured external competitive research funds including GRF, ECF, HMRF, and NNSFC.

https://orcid.org/0000-0001-8135-6030

https://scholar.google.com/citations?hl=zh-TW&user=raHFBbMAAAAJ&view_op=list_works&sortby=pubdate

Teaching Areas & Research Interests

• Pollutants and Human Health
• Epigenetic Transgenerational Effects of Pollutants
• Omics Technology and Big Data Analysis
• Drug Discovery

Selected Publications

Journal Articles

• Yang Y, Zhou GJ, Li Z, Sun J, Wong AST, Ko VCC, Wu RSS, Lai KP*. Effects of benzophenone-3 and its metabolites on the marine diatom Chaetoceros neogracilis: Underlying mechanisms and environmental implications. Sci Total Environ. 2024 May 1;923:171371.
• Luo J, Lana Y, Pana WW, Lai KP*, Kong D. Molecular mechanisms and biomarkers underlying the protective roles of the nutraceutical laminarin against ischaemic strokes. Food and Agricultural Immunology. 2023 Aug 34;1: 2249265.
• Ho TC, Wan HT, Lee WK, Lam TKY, Lin X, Chan TF, Lai KP, Wong CKC. Effects of In Utero PFOS Exposure on Epigenetics and Metabolism in Mouse Fetal Livers. Environ Sci Technol. 2023 Oct 10;57(40):14892-14903.
• Luo J, Chen D, Mei Y, Li H, Qin B, Lin X, Chan TF, Lai KP*, Kong D. Comparative transcriptome findings reveal the neuroinflammatory network and potential biomarkers to early detection of ischemic stroke. J Biol Eng. 2023 Aug 2;17(1):50.
• Zhou H, Wang P, Qin X, Zhang X, Lai KP*, Chen J. Comparative transcriptomic analysis and mechanistic characterization revealed the use of formononetin for bladder cancer treatment. Food Funct. 2023 Jun 19;14(12):5787-5804.
• Yang S, Li M, Kong RYC, Li L, Li R, Chen J, Lai KP*. Reproductive toxicity of micro- and nanoplastics. Environ Int. 2023 Jul;177:108002.
• Xu H, Liu J, Li X, Li J, Lin X, Li Z, Dou T, Gao L, Li R, Lai KP*. Instrumental and transcriptome analysis reveals the chemotherapeutic effects of doxorubicin-loaded black phosphate nanosheets on abiraterone-resistant prostate cancer. Bioorg Chem. 2023 Aug;137:106583.
• Lo HS, Wong LC, Lai KP*, Cheung SG. The influences of spatial-temporal variability and ecological drivers on microplastic in marine fish in Hong Kong. Environ Pollut. 2023 Jun 15;327:121527.
• Tam N, Kong RYC, Lai KP*. Reproductive toxicity in marine medaka (Oryzias melastigma) due to embryonic exposure to PCB 28 or 4'-OH-PCB 65. Sci Total Environ. 2023 May 20;874:162401.
• Qin X, Lin H, Cao Y, Wu RSS, Lai KP*, Kong RYC. Embryo developmental toxicity in marine medaka (Oryzias melastigma) due to parental and embryonic 17α-ethinylestradiol exposure. Sci Total Environ. 2022 Nov 28:160594.
• Lai KP*, Tim Leung CC, Boncan DAT, Tam N, Lin X, Wang SY, Chan TF, Sun Wu RS, Chong Kong RY. Hypoxia-induced epigenetic transgenerational miRNAs dysregulation involved in reproductive impairment of ovary. Chem Biol Interact. 2022 Sep 10;367:110176.
• Li R, Guo C, Lin X, Chan TF, Su M, Zhang Z, Lai KP*. Integrative omics analysis reveals the protective role of vitamin C on perfluorooctanoic acid-induced hepatoxicity. J Adv Res. 2021 Apr 15;35:279-294.
• Lu K, Lai KP, Stoeger T, Ji S, Lin Z, Lin X, Chan TF, Fang JK, Lo M, Gao L, Qiu C, Chen S, Chen G, Li L, Wang L. Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology. J Hazard Mater. 2021 Aug 15;416:126069.
• Tam N, Lai KP*, Kong RYC. Comparative transcriptomic analysis reveals reproductive impairments caused by PCBs and OH-PCBs through the dysregulation of ER and AR signaling. Sci Total Environ. 2022 Jan 1;802:149913.
• Qiao W, Wong KHM, Shen J, Wang W, Wu J, Li J, Lin Z, Chen Z, Matinlinna JP, Zheng Y, Wu S, Liu X, Lai KP, Chen Z, Lam YW, Cheung KMC, Yeung KWK. TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration. Nat Commun. 2021 May 17;12(1):2885.
• Li R, Li Y, Liang X, Yang L, Su M, Lai KP*. Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets. Brief Bioinform. 2021 Mar 22;22(2):1279-1290.
• Li R, Huang X, Liang X, Su M, Lai KP*, Chen J. Integrated omics analysis reveals the alteration of gut microbe-metabolites in obese adults. Brief Bioinform. 2021 May 20;22(3):bbaa165.
• Li R, Wu K, Li Y, Liang X, Lai KP*, Chen J. Integrative pharmacological mechanism of vitamin C combined with glycyrrhizic acid against COVID-19: findings of bioinformatics analyses. Brief Bioinform. 2021 Mar 22;22(2):1161-1174.
• Wan HT, Lai KP*, Wong CKC. Comparative Analysis of PFOS and PFOA Toxicity on Sertoli Cells. Environ Sci Technol. 2020 Mar 17;54(6):3465-3475.
• Lai KP, Wang SY, Li JW, Tong Y, Chan TF, Jin N, Tse A, Zhang JW, Wan MT, Tam N, Au DWT, Lee BY, Lee JS, Wong AST, Kong RYC, Wu RSS. Hypoxia Causes Transgenerational Impairment of Ovarian Development and Hatching Success in Fish. Environ Sci Technol. 2019 Apr 2;53(7):3917-3928.
• Lai KP, Wan HT, Ng AH, Li JW, Chan TF, Wong CK. Transcriptomic and Functional Analyses on the Effects of Dioxin on Insulin Secretion of Pancreatic Islets and β-Cells. Environ Sci Technol. 2017 Oct 3;51(19):11390-11400.
• Lai KP, Lee JC, Wan HT, Li JW, Wong AY, Chan TF, Oger C, Galano JM, Durand T, Leung KS, Leung CC, Li R, Wong CK. Effects of in Utero PFOS Exposure on Transcriptome, Lipidome, and Function of Mouse Testis. Environ Sci Technol. 2017 Aug 1;51(15):8782-8794.
• Lai KP*, Li JW, Cheung A, Li R, Billah MB, Chan TF, Wong CKC. Transcriptome sequencing reveals prenatal PFOS exposure on liver disorders. Environ Pollut. 2017 Apr;223:416-425.
• Lai KP*, Chung YT, Li R, Wan HT, Wong CK. Bisphenol A alters gut microbiome: Comparative metagenomics analysis. Environ Pollut. 2016 Nov;218:923-930.
• Wang SY, Lau K, Lai KP, Zhang JW, Tse AC, Li JW, Tong Y, Chan TF, Wong CK, Chiu JM, Au DW, Wong AS, Kong RY, Wu RS. Hypoxia causes transgenerational impairments in reproduction of fish. Nat Commun. 2016 Jul 4;7:12114.

Selected Professional & Community Services

• Member of State Key Laboratory of Marine Pollution, CityU (2015-now)
• Associate Director of Key Laboratory of Environmental Pollution and Integrative Omics, Guilin Medical University (2019-2024)

Further Information

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Link to Google Scholar page

Modified Date: 01 Mar, 2025
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